My place is close to the National Zoo, a great location in a nice area. I live 4 blocks from the Woodley Park/ Zoo/ Adam's Morgan metro station, which is 1 stop from Dupont Circle (nightlife) and 3 stops from downtown (National Mall area). My place is good for solo adventurers who are in town.
I've lived here for 8 years. DC is a great city and I can let you know about local attractions/events.